In this recent study, circulating tumor DNA (ctDNA) was measured in 17 metastatic uveal melanoma (UM) patients treated with protein kinase C inhibitor (PKCi)-based therapy. It concludes that longitudinal ctDNA monitoring is useful for monitoring disease response and progression in metastatic UM and is a valuable addition to adaptive clinical trial design.
Skin cancer screening is routinely performed for members of melanoma-prone families. The prupose of this recent study was to evaluate the efficacy of surveillance. The study concludes that participation in a longitudinal surveillance programme providing skin cancer screening and education about skin self-exams was associated with thinner melanomas for members of melanoma-prone families.
According to this recent study, just over 40% of melanomas diagnosed on shave biopsy report a positive deep margin; however, this translated into a change in tumor stage or treatment recommendations in relatively few patients (7.7% and 2.3%, respectively), with no impact on local recurrence or survival among the studies analyzed.
According to this recent study, the inverse approach, added to the classic pattern analysis, significantly improves the sensitivity of human readers for early lentigo maligna diagnosis.
According to this recent study, patients with advanced age, poor histologic differentiation, and American Joint Committee on Cancer T2 stage are at highest risk of developing subsequent cutaneous squamous cell carcinoma. Close clinical follow-up after the initial diagnosis is recommended.
Results of this recent study enhance the knowledge base for pembrolizumab in advanced melanoma, with no new toxicity signals after lengthy follow-up of a large population. In landmark analyses, pembrolizumab efficacy was similar regardless of immune-mediated adverse events or systemic corticosteroid use.
According to this recent study, eccentric hyperpigmentation in lesions is a robust criterion for malignancy, since the evaluation of the whole lesion, through an intralesional comparative approach, increases sensitivity.
The objective of this recent study was to determine whether histologically confirmed regression was associated with better or worse survival in patients with primary cutaneous melanoma. The study concludes that regression was a favorable prognostic factor for patients with stage 1 and 2 melanomas, especially in those with thin and intermediate thickness tumors and those with superficial spreading melanoma (SSM) subtype.
For this recent study, a selective literature search was performed by an international expert panel, focusing on the type of sunscreen to recommend for photoaging, skin cancers, photodermatoses, pigmentary disorders and skin inflammatory disorders. The study donclucdes that adapting the formulation and texture of the sunscreen to the type of skin and dermatoses is essential.
This study presents key findings highlighting the design and implementation approaches for a virtual reality health intervention primarily aimed at improving sun protection behaviors. This design approach can be applied to other health prevention programs in the future.