News and Events

Testing genomic variants helps predict melanoma risk

26 June 2018

Testing of genomic variants can identify people who are susceptible to melanoma despite not having a traditional phenotypic risk profile, according to this recent study which analysed data from Australia and the UK. 

Interferon Signaling Frequently Downregulated in Melanoma

25 June 2018

Melanoma responses to interferon-y are heterogeneous, frequently downregulated in immune checkpoint inhibitor-naïve melanoma and potentially predictive of response to immunotherapy, according to this recent study. 

Carcinogenic risk from UV nail lamps low

22 June 2018

Carcinogenic risk from UV nail lamps is low, however broad spectrum sunscreen with SPF >30, or protective gloves before UV nail lamp exposure is recommended, according to this recent study. 

ANZMTG Melanoma Margins Trial: a phase III randomised control trial investigating 1cm vs 2cm wide excision margins for primary cutaneous melanoma

20 June 2018

This feasibility study undertaken by the Australia and New Zealand Melanoma Trials Group (ANZMTG) was a phase III randomised control trial investigating 1cm vs 2cm wide excision margins for primary cutaneous melanoma. 

Results demonstrate the feasibility of a large international randomised control trial to provide a definitive answer to the optimal excision margin for patients with intermediate to high-risk primary cutaneous melanoma. Results also showed the rate of reconstruction is significantly increased when a wider margin is employed, which is consistent with previous randomised control trials. 

Genetic loci for tanning response to sun exposure identified

24 May 2018

This recent study used genetic data from almost 200,000 people of European ancestry to determine the genetics of sunburn and assess how these genes were responsible for protection from the sun. According to the study, almost all the genes involved in skin tanning were identified, which included 10 new genetic regions not previously identified. The results suggest the development of skin cancer can occur via two pathways: one dependent on skin pigmentation and the other independent of tanning ability.