According to this recent study, the use of immunosuppressive steroids for melanoma is associated with worse overall survival. Use of steroids should be limited when possible.
To increase understanding of the genomic landscape of acral melanoma, whole genome sequencing of 87 tumors with matching transcriptome sequencing for 63 tumors was performed in this recent study. Mutational signature analysis reveals a subset of tumors, mostly subungual, with an ultraviolet radiation signature.
One potential problem with the effectiveness of immunotherapies for cancers is the loss of interferon signaling in tumors, which impairs the effectiveness of both immune checkpoint blockade and cell-based therapies. According to this recent study, defective interferon signaling in tumors could be bypassed with the immunostimulatory compound BO-112.
This paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described.
According to this recent study, KRAS mutations could help identify patients with primary melanoma at higher risk of brain metastases who may benefit from more intensive, protracted surveillance.
According to this recent phase 3 trial, the efficacy, safety and on-treatment biomarker modulations associated with spartalizumab plus dabrafenib and trametinib in the treatment of metastatic melanoma are promising.
This recent clinical trial evaluated whether continuous or intermittent BRAF and MEK inhibition in patients with BRAF-mutated melanoma improved progression-free survival. Results showed continuous dosing yielded a statistically significant improvement in post-randomization progression-free survival compared with intermittent dosing.
This recent study examined the association between teacher duty schedule and skin cancer risk for school teachers of 1578 Queensland schools. It found timing of playground duty scheduling is a significant risk factor for keratinocyte skin cancers, and risks are lower in schools where there is more time between the first and second meal break.
According to five-year results from this CheckMate066 trial, there is significant benefit of nivolumab monotherapy as first-line treatment for patients with previously untreated BRAF wild-type advanced melanoma.
This recent study constructed a risk prediction model to determine the likelihood of carrying a heritable CDKN2A germline mutation among Australian families, where the prevalence of these mutations is low. According to the study, the model will help to effectively identify families suitable for genetic counselling and testing in areas of high ambient ultraviolet radiation.