11 August 2020
SOX10 is a highly specific marker for melanoma metastasis in lymph nodes, comparable with pS100. According to this recent study, SOX10 has the same level of recommendation as pS100 for the detection of melanoma metastasis in sentinel lymph node protocols. The interpretation of SOX10 staining is highly reproducible among different centres and different pathologists because of the absence of staining of immune cells.
11 August 2020
Sentinel node biopsy status in high risk stage IIB and IIC melanoma patients remains the most important prognostic information when determining likelihood of recurrence and mortality, according to this recent retrospective analysis.
4 August 2020
This recent review analysed the performance of commercially available gene expression profile tests in predicting cutaneous melanoma outcomes in patients with stage I or stage II melanoma. In patients with clinically localized melanoma there was variation in gene expression profile test performance by disease stage, suggesting limited potential for clinical utility for patients with stage I melanoma.
1 August 2020
This recent review looks at the current clinical development status of human intratumoural immunotherapy (HIT-IT) in the management of unresectable and metastatic melanoma. Early data indicates a synergy between HIT-IT and immune checkpoint inhibitors, suggesting future clinical use will focus on the combined use of these agents.
1 August 2020
According to this recent study, internet based learning is a promising approach to delivering clinical skin examination skills to primary care nurse practitioners.
1 August 2020
According to this recent randomised control trial conducted in Arkansas, educational videos used in cosmetology schools increase student's ability to recognise potential skin cancers and talk with clients about sun safety and consulting a dermatologist about suspicious moles.
18 July 2020
This recent study examined the clinical-pathological significance of Leptin receptor (LEPR) expression in squamous cell carcinoma of the skin. It found LEPR expression to be a predictor of the malignant potential of squamous cell carcinoma. This provides the possibility of individualizing anti-tumor treatment using LEPR antagonists.
18 July 2020
This recent study tested the effectiveness of UV detection stickers to improve sunscreen use in adolescents playing outdoor sports. It found a greater than 3-fold improvement in sunscreen use when the UV detection stickers were provided.
18 July 2020
This systematic review examined the impact of biopsy technique on clinically important outcomes for cutaneous melanoma. Findings identified a small but statistically significant increase in all-cause mortality for punch biopsies used to diagnose cutaneous melanoma, giving further support to the current clinical practice guidelines for the evaluation of pigmented lesions suspected for the diagnosis of cutaneous melanoma.
16 July 2020
This multicentric collaborative study conduced by the International Dermoscopy Society analyses dermatoscopic features of thin (≤ 2mm Breslow thickness) versus thick (> 2mm Breslow thickness) nodular melanoma and predictors of nodular melanoma versus nodular non‐melanoma tumors. It concludes that dotted vessels, white shiny streaks and irregular blue structureless area were predictors for thinner nodular melanoma compared to non‐melanoma nodular tumors.
